The Proximal Origin of SARS-CoV2 -- Special Report -- J.C. ON A BIKE

On the road again, this time covering the new Nature Medicine Correspondence paper titled, "The Proximal Origins of SARS-CoV2" and second paper in Nature titled, "Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins".

Summary at 21:15

I am pretty critical of the Nature Medicine paper because there are some key omissions from the bibliography that suggest ulterior motives.

The first FIVE papers to ask any expert about (eg. Prof. Olsterholm) are marked with stars in the bibliography below.

You can read all the science yourself, although it is cutting edge biology that won’t be fun reading for the non-biologist.

Big Shout out to Dan's recent work on this subject: https://harvardtothebighouse.com/2020/01/31/logistical-and-technical-analysis-of-the-origins-of-the-wuhan-coronavirus-2019-ncov/ https://harvardtothebighouse.com/2020/03/19/china-owns-nature-magazines-ass-debunking-the-proximal-origin-of-sars-cov-2-claiming-covid-19-wasnt-from-a-lab/

What follows is a quick and dirty annotated bibliography that I think shows we COULD have made SARS-CoV2.

It doesn’t prove we or anyone else made it. But it definitely shows we could. I am not saying we or anyone else would. I am not saying I know who did.

I am specifically saying that to say, “We couldn’t have made this virus” is absolutely false as best as I can tell.

I am specifically saying that we have already collected, cultured, and even made similar viruses (see below).

PNAS paper 2000 showing techniques to use cDNA to generate RNA viruses:

** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25860/

Commentary on above: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC33981/

Two papers using Ferrets for gain of function research in H5N1 flu virus:

** https://www.ncbi.nlm.nih.gov/pubmed/22723413

** https://www.ncbi.nlm.nih.gov/pubmed/22722205

A few papers showing how fun it is to collect bat viruses in the wild:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4687304/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6466186/

(This last one uses the ACE2 receptor?! And has Peter Daszak as 2nd to last author next to Zhengli Shi bat woman of Wuhan)

** https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389864/

Nice articles about the Gain-of-Function Debate, viruses as weapons:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542197/

https://www.sciencemag.org/news/2011/11/scientists-brace-media-storm-around-controversial-flu-studies (This article quotes Osterholm about H5N1 papers above!)

A few papers to start with regarding the making of our own chimeric bat coronaviruses:

** https://www.nature.com/articles/nm.3985/ (Ralph Baric, Zhengli Shi/batwoman again)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4006927/

The paper with a culture prep to study viruses and lung epithelium interactions:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4744394/

A few papers regarding the crystallography of coronaviruses:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4338876/

A couple coronavirus reviews:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369385/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4465284/

Cut and paste the following five paper link list as part of spreading the word about gain of function viral research!

This is an ultra-short smack on point bibliography (starred papers above) that could easily be expanded to hundreds of papers:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC25860/ https://www.ncbi.nlm.nih.gov/pubmed/22723413 https://www.ncbi.nlm.nih.gov/pubmed/22722205 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389864/
https://www.nature.com/articles/nm.3985/

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J.C. is an academic [neuro]biologist turned bike-seat science journalist who moved to Pittsburgh in 2016.

After nearly 20K miles on the streets of the City of Champions, J.C. has come to see Pittsburgh as home. Thanks for watching!

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Music by Joakim Karud https://youtube.com/joakimkarud ... https://www.youtube.com/watch?v=HmSCMb8Nds4