Las Quorum sensing System | Pseudomonas aeruginosa | Microbiology | Basic Science Series

Las Quorum sensing System | Pseudomonas aeruginosa | Microbiology | Basic Science Series Keywords: Pseudomonas aeruginosa, Quorum sensing, Las system, Bacterial communication, LasI, LasR, 3-oxo-C12-HSL, Bacterial signaling, Gene regulation, Biofilm formation, Antibiotic resistance, Nosocomial infections, Bacterial adaptability, Bacterial resilience, Bacterial behavior synchronization, Basic science series, Microbial communication, Pathogenic bacteria, Molecular messages, Bacterial membrane, Transcriptional activator, Genetic responses, Bacterial motility, Soil bacteria, Hospital-acquired infections • Introduction to Pseudomonas aeruginosa: • Pseudomonas aeruginosa is a versatile bacterium thriving in diverse environments, from soil to hospital settings. • It exhibits adaptability and resilience and is notorious for causing nosocomial infections due to its opportunistic nature.

• Understanding Quorum Sensing: • Quorum sensing is likened to bacteria acting as tiny chatterboxes, constantly exchanging molecular messages to coordinate their activities. • In the case of P. aeruginosa, the Las quorum sensing system serves as its communication network, synchronizing behavior based on population density.

• The Las Quorum Sensing Cascade: • Core components: LasI and LasR. • LasI synthesizes a signaling molecule called 3-oxo-C12-HSL, while LasR acts as the receptor. • At a certain population density, 3-oxo-C12-HSL binds to LasR, initiating a cascade of events.

• LasI Synthesis and Binding to LasR: • LasI produces 3-oxo-C12-HSL, which diffuses through the bacterial membrane. • As its concentration increases, it binds to LasR, altering its confirmation and activating its role as a transcriptional activator.

• Gene Regulation and Beyond: • Active LasR binds to specific DNA sequences, influencing gene expression. • Genes involved in critical functions like biofilm formation, motility, and antibiotic resistance are affected. • This coordination of genetic responses enables P. aeruginosa to adapt to its environment and exert pathogenic abilities.

• Conclusion: • The Las quorum sensing system of Pseudomonas aeruginosa orchestrates population-wide coordination, enabling adaptability and pathogenicity. • Further insights into basic sciences will be shared in future episodes. Stay tuned and remember to engage by liking, sharing, and subscribing to the Basic Science Series. • WhatsApp group: https://chat.whatsapp.com/HTXQC1Ax2qfKYa3MrZiMeD Twitter: https://twitter.com/basic_series Facebook Group: https://www.facebook.com/groups/742235929758671 LinkedIn: https://www.linkedin.com/in/basic-science-series-a54439208/ Instagram: https://www.instagram.com/basic_science_series/ Support my work at https://www.patreon.com/user?u=37177596

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