Antigen Presentation | Structure | Illustration | Design with MS power point | Basic Science Series

Dendritic Cell Antigen Presentation | Structure | Illustration | Design using MS power point | Basic Science Series

Keywords: Dendritic cells, Immune response, Antigen presentation, Foreign pathogens, CD8+ T cells, Major histocompatibility complex (MHC) class I molecules, Cross-presentation, Exogenous antigens, Cancer cells, Intracellular pathogens, Tumor antigens, MHC class II molecules, CD4+ T cells, Phagosomes, Antigen processing, Endoplasmic reticulum, Antigenic peptides.

Dendritic cells are a type of immune cell that play a key role in initiating and regulating immune responses. One of their important functions is antigen presentation, in which they capture and present antigens from foreign pathogens to other immune cells, such as T cells and B cells, to trigger an immune response. Dendritic cells can also perform a specialized form of antigen presentation called cross-presentation, which involves the presentation of exogenous antigens, such as those from viruses or cancer cells, on major histocompatibility complex (MHC) class I molecules to activate CD8+ T cells. This process is important for generating effective immune responses against intracellular pathogens and tumors, which typically produce antigens that are not presented on MHC class II molecules and therefore cannot be directly recognized by CD4+ T cells. Cross-presentation involves several steps, including antigen uptake by dendritic cells, processing of the antigen in specialized compartments called phagosomes, and transport of the antigenic peptides to the endoplasmic reticulum for loading onto MHC class I molecules. This process requires the activity of several specialized proteins and chaperones, including TAP and tapasin, which help to ensure that the correct antigenic peptides are loaded onto MHC class I molecules for presentation to CD8+ T cells.

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