The Root Cause of Insulin Resistance

What Causes Insulin Resistance? | Does Fat Cause Type 2 Diabetes?

Insulin resistance, which precedes type 2 diabetes, is one of the biggest problems in human history– that isn’t an exaggeration. This condition is linked to nearly every modern disease imaginable, and ultimately costing millions of lives and trillions of dollars. In this video, we show you how insulin resistance starts, how it progresses, and how it invades every part of you. Is it purely a hormonal balance? Can we cure or reverse type 2 diabetes?

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REFERENCES:

Hyperinsulinemia and insulin resistance drive each other: https://care.diabetesjournals.org/content/31/Supplement_2/S262.long mTOR signaling in different tissues: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6073766/ Oxidative stress and diabetes: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2996922/ Mechanisms of insulin resistance: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6170977/ Adipose hyperplasia protects against IR: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920141/ Differences in adipocyte count between Diabetic and nondiabetic women: https://academic.oup.com/jcem/article/99/8/E1466/2537438 Thiazolidinediones mechanism: https://www.ncbi.nlm.nih.gov/books/NBK551656/ Free fatty acids in IR: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4587882/ Mitochondrial overload leading to DAG and ceramide production: https://www.cell.com/cell-metabolism/fulltext/S1550-4131(07)00306-3?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS1550413107003063%3Fshowall%3Dtrue Oxidized LA metabolites in FLD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4578804/ Pathogenesis of NAFLD: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7109346/#hep41479-bib-0026 Hypothalamic IR: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6471380/ Ceramide synthesis: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204836/ Diacylglycerol accumulation: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730126/#S4title NAFLD and diabetes: https://www.nature.com/articles/nrdp201581

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